MS Rituximab Gives An Opportunity To Live Almost Symptom Free For One Year

In ms rituximab,it reduced the number of inflammatory brain lesions and the number of clinical relapses that occurred over one year in patients with multiple sclerosis in a clinical trial published in the New England of Medicine.

Here are some recommendations for the management of MS from the National Institute for Clinical Excellence (NICE):

• Remember that some people with MS, even those without obvious disability, may not be able to follow everything fully or remember complex details.

As a result, be straightforward, check that your patient has understood you, back up what you said with written (and other) material, and reinforce information as necessary.

• Patients with MS may benefit from emotional support. Where possible, meet that emotional need directly or through referral to a suitable resource.

• Give patients with MS relevant and accurate information about each choice and decision to enable them to play an active part in making informed decisions in all aspects of their MS health care.

As part of a phase 2, double-blind, randomized trial, researchers gave 69 patients with relapsing-remitting MS 1,000 mg of intravenous rituximab and 35 MS patients a placebo on days 1 and 15. The participants underwent MRI of the brain at weeks 12, 16, 20, and 24.

Compared with placebo, use of rituximab was associated with the presence of fewer gadolinium-enhancing lesions at all four time points – a result that was sustained through 48 weeks.

In addition, a smaller proportion of rituximab-treated patients were experiencing a relapse of MS symptoms at weeks 24 and 48.

Adverse events associated with rituximab occurred primarily after the first infusion and were generally mild-to-moderate in nature.

Today’s research highlights the therapeutic role of rituximab in relapsing-remitting MS, suggesting that B lymphocyte activity plays a role in the pathology of this condition. For Insidermedicine in Depth.

Quote Of The Day

"How far you go in life depends on your being tender with the young, compassionate with the aged, sympathetic with the striving, and tolerant of the weak and strong. Because someday in your life you will have been all of these. " -- George Washington Carver, Botanist From ms rituximab to treatment

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